Cryogenics free production of hyperpolarized 129Xe and 83Kr for biomedical MRI applications
نویسندگان
چکیده
منابع مشابه
Molecular hydrogen and catalytic combustion in the production of hyperpolarized 83Kr and 129Xe MRI contrast agents.
Hyperpolarized (hp) (83)Kr is a promising MRI contrast agent for the diagnosis of pulmonary diseases affecting the surface of the respiratory zone. However, the distinct physical properties of (83)Kr that enable unique MRI contrast also complicate the production of hp (83)Kr. This work presents a previously unexplored approach in the generation of hp (83)Kr that can likewise be used for the pro...
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Introduction The hyperpolarization (HP) technique can increase the signal sensitivity of nuclear magnetic resonance (NMR) ten thousand times for He and Xe, and thus it enables instantaneous imaging of cavity gases [1, 2]. This technology has been expected to be a practical technology for the development of medical equipment that enables instantaneous evaluation of lung functions, and the early ...
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PURPOSE To develop and optimize a rapid dynamic hyperpolarized 129 Xe ventilation (DXeV) MRI protocol and investigate the feasibility of capturing pulmonary signal-time curves in human lungs. THEORY AND METHODS Spiral k-space trajectories were designed with the number of interleaves Nint = 1, 2, 4, and 8 corresponding to voxel sizes of 8 mm, 5 mm, 4 mm, and 2.5 mm, respectively, for field of...
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Many applications of MRI are limited by an inherently low sensitivity. Previous attempts to overcome this insensitivity have focused on the use of MRI systems with stronger magnetic fields. However, the gains that can be achieved in this way are relatively small and increasing the magnetic field invariably leads to greater technical challenges. More recently, the development of a range of techn...
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ژورنال
عنوان ژورنال: Journal of Magnetic Resonance
سال: 2013
ISSN: 1090-7807
DOI: 10.1016/j.jmr.2013.09.008